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We studied 13 patients with severe drug-induced parkinsonism(DIP)using L- 6-[18F]fluorodopa positron emission tomography(18F-dopa PET)to investigate the integrity of their dopaminergic nigrostriatal projections.Twelve of these patients were subsequently followed clinically for a median of 23.5 months(range,6 to 49).Nine patients had normal putamen 18F-dopa uptake.In eight of these nine patients where follow-up was available,a normal 18F- dopa PET study was predictive of subsequent improvement of parkinsonism. Four of 13 DIP(31%)had significantly reduced putamen 18F-dopa uptake, within the Parkinson's disease range,and in three of these four(75%),this reduction was associated with continued,or worsening,parkinsonism.There were no clinical features at the time of PET that distinguished those who recovered and those who did not.We conclude that a normal 18F-dopa PET study correlates well with improvement from DIP,but an abnormal study does not necessarily indicate a poor prognosis. |
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CAT scan,emission
CAT scan,emission,abnormal
Parkinson disease
Parkinson disease,drug induced
Parkinsonism syndrome
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