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There was no significant difference in overall mean scores on the Scandinavian Stroke Scale.No increase in bleeding occurred in the ancrod- treated patients.The target reduction of plasma fibrinogen levels of less than 100 mg/dL was achieved in only 15(23%)of 64 ancrod-treated patients. Those patients with ancrod-induced 6-hour fibrinogen levels 130 mg/dL or less had a marginally significantly better neurologic outcome on the Scandinavian Stroke Scale,mortality,and Barthel Index than ancrod-treated patients with higher fibrinogen levels.Ancrod appears safe and potentially effective when administered to patients within 6 hours of onset of ischemic stroke. |
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