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Hereditary Neuralgic Amyotrophy & Hereditary Neuropathy with Liability to Pressure Palsies:Distinct Genetic Dis
Neurol 44:2253-2257, Chance,P.F.,et al, 1994
See this aricle in Pubmed

Article Abstract
Hereditary neuralgic amyotrophy with predilection for the brachial plexus (HNA)and hereditary neuropathy with liability to pressure palsies(HNPP)are autosomal dominant disorders associated with episodic,recurrent brachial neuropathies.HNPP is associated with a deletion or abnormal structure of the PMP22 gene on chromosome 17p11.2-12.The genetic locus for HNA is unknown.To address the possibility that HNPP and HNA might be identical disorders or allelic variations at the same locus,we investigated three HNA pedigrees with markers from the HNPP region.We did not find the 17p11. 2-12 deletion associated with HNPP,nor an abnormality in PMP22 structure with HNA.This analysis provides genetic evidence,in addition to that suggested by the clinical,electrophysiologic,and pathologic differences, that HNA and HNPP are distinct disorders.
 
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brachial neuritis
brachial plexus neuropathy,familial
chromosome 17
compression neuropathy
familial
gene
molecular genetics
neuropathy
neuropathy,hereditary peripheral
tomaculous neuropathy

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