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Intellectual Impairment in Children Exposed to Polychlorinated Biphenyls in Utero
NEJM 335:783-789, Jacobson,J.L.,et al, 1996
See this aricle in Pubmed
Article Abstract
Prenatal exposure to polychlorinated biphenyls was associated with lower full scale and verbal IQ scores after control for potential confounding variables such as socioeconomic status(P=0.02).The strongest effects related to memory and attention.The most highly exposed children were three times as likely to have low average IQ scores(P<0.001)and twice as likely to be at least two years behind in reading comprehension(P=0.03). Although larger quantities of polychlorinated biphenyls are transferred by breast-feeding than in utero,there were deficits only in association with transplacental exposure suggesting that the developing fetal brain is particularly sensitive to these compounds.In utero exposure to polychlorinated biphenyls in concentrations slightly higher than those in the general population can have a long term impact on intellectual function.
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intellectual deficit
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intelligence testing in children
intrauterine
neurotoxin
polychlorinated biphenyls
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