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Effectiveness of High-Dose Riboflavin in Migraine Prophylaxis, A Randomized Controlled Trial
Neurol 50:466-470, Schoenen,J.,et al, 1998
See this aricle in Pubmed

Article Abstract
A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis.We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis.We now compared riboflavin(400mg)and placebo in 55 patients with migraine in a randomized trial of 3 months duration.Using an intention-to-treat analysis,riboflavin was superior to placebo in reducing attack frequency(p=0.005)and headache days(p=0.012). Regarding the latter,the proportion of patients who improve by at least 50%,i.e."responders,"was 15%for placebo and 59%for riboflavin(p=0.002)and the number-needed-to-treat for effectiveness was 2.3.Three minor adverse events occurred,two in the riboflavin group(diarrhea and polyuria)and one in the placebo group(abdominal cramps).None was serious.Because of its high efficacy,excellent tolerability,and low cost,riboflavin is an interesting option for migraine prophylaxis and a candidate for a comparative trial with an established prophylactic drug.
 
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headache
migraine
migraine,prophylaxis
migraine,treatment of
riboflavin
treatment of neurologic disorder
vitamin therapy

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