Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Clinical,Radiological,Neurophysiological,and Neuropathological Characteristics of Gluten Ataxia
Lancet 352:1582-1585, Hadjivassiliou,M.,et al, 1998
See this aricle in Pubmed

Article Abstract
28 patients with gluten ataxia were identified. All had gait ataxia and most had limb ataxia. Those with more severe gait ataxia had longer disease duration. No patient had tremor or other extrapyramidal features. 19 patients showed some form of peripheral neuropathy on neurophysiological examination. 16 patients had no gastrointestinal symptoms. Distal duodenal biopsy showed lymphocytic infiltration in two patients, and changes compatible with coeliac disease in 11. Six patients had evidence of cerebellar atrophy on magnetic resonance imaging. Necropsy was done on two patients who died; there was lymphocytic infiltration of the cerebellum, damage to the posterior columns of the spinal cord, and sparse infiltration of the peripheral nerves. Gluten sensitivity is an important cause of apparently idiopathic ataxia and may be progressive. The ataxia is a result of immunological damage to the cerebellum, to the posterior columns of the spinal cord, and to peripheral nerves. We propose the term gluten ataxia to describe this disorder.
 
Related Tags
(click to filter results - removes previous filter)

ataxia
ataxic gait
celiac disease,adult
cerebellar atrophy,secondary
cerebellar degeneration
cerebral cortical atrophy
gait disorder
gliadin antibodies
gluten sensitivity
intestinal biopsy
MRI
MRI,abnormal
neuropathology
neuropathy
Purkinje cell
serologic testing

Click Here to return To Results