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Pertussis Encephalopathy with High Cerebrospinal Fluid Antibody Titers to Pertussis Toxin and Filamentous Hemagglutinin
Pediatrics 102:986-990, Grant,C.C.,et al, 1998
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Article Abstract
A 7 year old unimmunized girl with pertussis presented with respiratory failure and electroencephalographic evidence of an encephalopathy. The cerebrospinal fluid (CSF)/serum ratio of antibodies to pertussis toxin and filamentous hemagglutinin were 11 and ninefold higher than the CSF/serum ratio of total immunoglobulin G. the CSF/serum ratio of albumin was normal. These findings indicate production of antibodies in the central nervous system to Bordetella pertussis antigens and imply, therefore, that the pertussis encephalopathy in this girl was associated with the entry of pertussis antigens into the central nervous system.
 
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bacterial infection
central hypoventilation
cerebrospinal fluid
cerebrospinal fluid,abnormal
children
cough
electroencephalogram,abnormalities of
encephalopathy
level of consciousness,decreased
neurologic signs
neurotoxin
pertussis
polymerase chain reaction,false negative
respiratory failure
seizure
serologic testing
serologic testing of cerebrospinal fluid
toxins,nervous system

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