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Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations
NEJM 362:2185-2193, Jentink,J., et al, 2010
See this aricle in Pubmed
Article Abstract
The use of valproic acid monotherapy in the first trimester was associated with significantly increased risks of several congenital malformations, as compared with no use of antiepileptic drugs or with use of other antiepileptic drugs.
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