[home]
[thesaurus]
Click Here to return To Results
Neuroimaging and Clinical Features in Type II (late-onset) Alexander Disease
Neurol 82:49-56, Graff-Radford, J.,et al, 2014
See this aricle in Pubmed
Article Abstract
Our study confirms prior reports of atrophy and signal change of the medulla and spinal cord in late-onset AxD. We expand on previous imaging studies by identifying middle cerebellar peduncle and pial FLAIR signal changes as important diagnostic clues. Variable patchy enhancement may occur in regions of T2 hyperintensity, leading to diagnostic clues. Variable patchy enhancement may occur in regions of T2 hyperintensity, leading to diagnostic uncertainty. In addition, we demonstrate that previously emphasized clinical features such as palatal tremor may not be common. We affirm that age at onset predicts clinical phenotype and imaging findings.
Related Tags
(click to filter results - removes previous filter)
Alexanders disease
Alexanders disease,adult onset
autonomic dysfunction
basal ganglia,lesion of
brainstem,lesion of
dysarthria
dysphagia
gait disorder
GFAP gene
hyperreflexia
leukodystrophy
medulla oblongata,lesion of
MRI,abnormal
Rosenthal fibers
seizure
spasticity
spinal cord,lesion of
white matter disease
Click Here to return To Results