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Clinical, Genetic, and Radiological Features of Extrapyramidal Movement Disorders in Mitochondrial Disease
JAMA Neurol 73:668-674, Martikainen, M.H.,et al, 2016
See this aricle in Pubmed

Article Abstract
Dystonia, often associated with Leigh syndrome, was the most common extrapyramidal movement disorder among pediatric patients with mitochondrial disease. Parkinsonism was the most prevalent extrapyramidal movement disorder in adults and was commonly associated with POLG mutations: dystonia was predominantly associated with mitochondrial DNA mutations. These findings may help direct genetic screening in a busy neurology outpatient setting.
 
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basal ganglia,lesion,bilateral
children
chorea
dystonia
Leigh's disease
mitochondrial disease
movement disorder
movement disorder,extrapyramidal
MRI,abnormal
Parkinson disease
POLG1 gene
restless leg syndrome

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