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Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing
JAMA Neurol 75:947-955,915, Wilson,M.R.,et al, 2018
See this aricle in Pubmed

Article Abstract
Diverse microbial pathogens wee identified by mNGS in the CSF of patients with diagnostically challenging subacute or chronic meningitis, including a case of subarachnoid neurocysticercosis that defied diagnosis for 1 year, the first reported case of CNS vasculitis caused by Aspergillus oryzae, and the fourth reported case of C dubliniensis meningitis. Priortizing metagenomic data with a scoring algorithm greatly clarified data interpretation and highlighted the problem of attributing biological significance to organisms present in control samples used for metagenomic sequencing studies.
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cerebrospinal fluid
cerebrospinal fluid,abnormal
meningitis,viral etiology in
neurologic disease,diagnoses of
next-generation sequencing

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