Lecanemab in Early Alzheimers Disease
NEJM 388:9-21,80, van Dyck,A.H.,et al, 2023
Intravenous Thrombolysis Use in the Late Time Window Before Interhospital Transfer for Thrombectomy
JAMA Neurol 83:60-67, Seners,P.,et al, 2026
Endovascular Therapy for Patients with Low NIHSS Scores and Large Vessel Occlusion in the 6- to 24-Hour Window
Neurol 104:e213442, Marto,J.P.,et al, 2025
Alteplase for Posterior Circulation Ischemic Stropke at 4.5 to 24 Hours
NEJM 392:1288-1296, Yan,S.,et al, 2025
Small Step or Giant Leap? Expanding the Acute Stroke Thrombolysis Window to 24 Hour
NEJM 391:273-275, Lee,V.H., 2024
Diffusion-Weighted Imaging Fluid-Attenuated Inversion Recovery Mismatch on Portable, Low-Field Magnetic Resonance Imaging Amont Acute Stroke Patients
Ann Neurol 96:321-331, Sorby-Adams,A.,et al, 2024
Effect of IV Thrombolysis With Alteplase in Patients with Vessel Occlusion in the WAKE-UP Trial
Neurol 104:e209871, Galinovic,I.,et al, 2024
Favorable Outcomes in Endovascular Therapy for Basilar-Artery Occlusion
NEJM 387:1428-1429, Schonewille, W.J.,et al, 2022
Thrombolysis for Acute Ischemic Stroke in the Unwitnessed or Extended Therapeutic Time Window
Neurol 94:e1241-e1248, Tsivgoulis, G.,et al, 2020
Lesion Age Imaging in Acute Stroke: Water Uptake in CT Versus DWI-FLAIR Mismatch
Ann Neurol 88:1144-1152, Broocks, G.,et al, 2020
MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
NEJM 379:611-622, 682, Thomalla, G.,et al, 2018
Intravenous Thrombolysis in Unwitnessed Stroke Onset: MR WITNESS Trial Results
Ann Neurol 83:980-993, Schwamm, L.H.,et al, 2018
Implications of the WAKE-UP Trial
Stroke 49:3115-3117, Silver, B. & Arnold, M., 2018
Reduction in Time to Treatment in Prehospital Telemedicine Evaluation and Thrombolysis
Neurol 88:1305-1312, Taqui, A.,et al, 2017
Favorable Bridging Therapy Based on DWI-FLAIR Mismatch in Patients with Unclear-Onset Stroke
AJNR 37:88-93, Mourand, I.,et al, 2016
Clinicopathologic Conference, Cerebral Infarction from Internal Carotid Occlusion Related to Sickle Cell Arteriopathy
NEJM 374:1265-1275, Case 10-2016, 2016
Implementing a Mobile Stroke Unit Program in the United States
JAMA Neurol 72:229-234, Rajan, S.,et al, 2015
Effects of Golden Hour Thrombolysis
JAMA Neurol 72:25-30,9, Ebinger, M.,et al, 2015
Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke
NEJM 372:2285-2295,2347, Saver, J.L.,et al, 2015
Thrombectomy within 8 hours after Symptom Onset in Ischemic Stroke
NEJM 372:2296-2306,2347, Jovin, T.G.,et al, 2015
Screening with MRI for Accurate and Rapid Stroke Treatment
Neurol 84:2438-2444, 2394, Shah, S.,et al, 2015
Treatment Concepts for Wake-Up Stroke and Stroke with Unknown Time of Symptom Onset
Stroke 46:2707-2713, Thomalla, G. & Gerloff, C., 2015
Treatment of Patients with Suspected Ischemic Stroke of Undetermined Onset and Negative Head Computed Tomography Scan
Stroke 44:1494-1495, Adams, H., 2013
A Plain Computed Tomography Scan is Sufficient to Consider Thrombolysis in Patients with Unknown Time of Onset
Stroke 44:1492-1493, Alexandrov, A., 2013
Diagnosis and Management of Cerebral Venous Thrombosis: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Stroke 42:1158-1192, Saposnik,G.,et al, 2011
Helicopter Transport of Stroke Patients and Its Influence on Thrombolysis Rates
Stroke 42:1295-1300, Reiner-Deitemyer, V.,et al, 2011
Remote Supervision of IV-tPA for Acute Ischemic Stroke by Telemedicine or Telephone Before Transfer to a Regional Stroke Center Is Feasible and Safe
Stroke 41:e18-e24, Pervez,M.,et al, 2010
Time to Treatment With Intravenous Alteplase and Outcome in Stroke: An Updated Pooled Analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
Lancet 375:1695-1703, 1667, Lees, K.R., et al, 2010
4.5 Hours: The New Time Window for Tissue Plasminogen Activator in Stroke
Stroke 40:2266-2267, Davis,S.M. &Donnan,G.A., 2009
Influence of the Stroke Code Activation Source on the Outcome of Acute Ischemic Stroke Patients
Neurol 70:1238-1243,1232, P�rez de la Ossa,N.,et al, 2008
Population-Based Analysis of the Impact of Expanding the Time Window for Acute Stroke Treatment
Stroke 38:3213-3217, Juhl,J.,et al, 2007
Prioritizing interventions to Improve Rates of Thrombolysis for Ischemic Stroke
Neurol 64:654-659, California Acute Stroke Pilot Registry (CASPR) Inv, 2005
Vertebrobasilar Disease
NEJM 352:2618-2626, Savitz,S.I.&Caplan,L.R., 2005
Association of Outcome with Early Stroke Treatment:Pooled Analysis of ATLANTIS, ECASS, and NINDS rt-PA Stroke Trials
Lancet 363:768-774, The ATLANTIS,ECASS,and NINDS rt-PA Study Group, 2004
Cuahoga County Operation Stroke Speed of Emergency Department Evaluation and Compliance with National Institutes of Neurological Disorders and Stroke Time Targets
Stroke 34:994-998, Katzan,I.L.,et al, 2003
Thrombolysis in Stroke Beyond Three Hours: Targeting Patients With Diffusion and Perfusion MRI
Ann Neurol 51:11-13,28, Warach,S., 2002
Why Are Stroke Patients Excluded from TPA Therapy?
Neurol 56:1015-1020, Barber,P.A.,et al, 2001
Early Stroke Treatment Associated with Better Outcome
Neurol 55:1649-1655, Marler,J.R.,et al, 2000
I. V. t-PA for Acute Ischemic Stroke, Feasibility, Safety & Efficacy in the First Year of Clinical Practice
Stroke 29:18-22, Chiu,D.,et al, 1998
Total Quality Improvement Method for Reduct of Delays Between ER Dept Adm & Trtm of Acute Ischemic Stroke
Arch Neurol 54:1466-1474, Tilley,B.C.,et al, 1997
Urgent Therapy for Stroke Part I, Pilot Study of Tissue Plasminogen Activator Administered within 90 Minutes
Stroke 23:632-640, Brott,T.G.,et al, 1992
Tenecteplase for Acute Non-Large Vessel Occlusion 4.5 to 24 Hours After IschemicStroke, The OPTION Randomized Clinical Trial
JAMA doi:10.1001/JAMA.2026.0210, Ma,G.,et al, 2026
A Randomized Trial of Tenecteplase in Acute Central Retinal Artery Occlusion
NEJM 394:442-450, Ryan,S.J.,et al, 2026
Safety and Outcomes of Dibigatran Reversal with Idarucizumab Before IV Thrombolysis in Patients with Acute Ischemic Stroke
Neurol 106:e218012, Saflund,M.,et al, 2026
Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients with Moyamoya Disease
Neurol 104:e210243, Chen,H.,et al, 2025
Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion
NEJM 392:1385-1395,1440, Goyal,lM.,et al, 2025
Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels
NEJM 392:1374-1384,1440, Psychogios,M.,et al, 2025
Endovascular Thrombectomy for Large Ischemic Core Stroke, A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Neurol 104:e213443, Liu,C.,et al, 2025
Intravenous Tenecteplase before Thrombectomy in Stroke
NEJM 393:139-150, Qiu,Z.,et al, 2025